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Test Code TQ10 Coenzyme Q10, Total, Plasma

Useful For

Diagnosis of primary coenzyme Q10 (CoQ10) deficiencies in some patients who are not supplemented with CoQ10

 

Monitoring patients receiving statin therapy

 

Monitoring CoQ10 status during treatment of various degenerative conditions, including Parkinson and Alzheimer diseases

 

Providing accurate quantitation of total CoQ10 when specimens are hemolyzed

 

This test is not useful for distinguishing primary CoQ10 deficiencies from acquired CoQ10 deficiencies.

Method Name

High-Performance Liquid Chromatography (HPLC) with Electrochemical Detection

Reporting Name

Coenzyme Q10, Total, P

Specimen Type

Plasma Heparin


Ordering Guidance


This test does not quantitate reduced coenzyme Q10. For reduced coenzyme Q10 (CoQ10), order Q10 / Coenzyme Q10, Reduced and Total, Plasma.

 

The most reliable test for the diagnosis of primary defects in ubiquinone (ie, CoQ10) biosynthesis is direct measurement of CoQ10 in muscle.



Necessary Information


Patient's age is required.



Specimen Required


Patient Preparation: Fasting (8 hours)

Collection Container/Tube: Green top (lithium or sodium heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Immediately after collection, place specimen on wet ice. Maintain on wet ice and process within 3 hours of collection.

2. Centrifuge, aliquot plasma into plastic vial, and freeze immediately.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Heparin Frozen (preferred) 14 days
  Refrigerated  10 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Reference Values

<18 years: 320-1558 mcg/L

≥18 years: 433-1532 mcg/L

 

Miles MV, Horn PS, Tang PH, et al. Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults. Clin Chim Acta. 2004;34:139-144

Day(s) Performed

Monday through Friday

Report Available

2 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TQ10 Coenzyme Q10, Total, P 27923-2

 

Result ID Test Result Name Result LOINC Value
36764 CoQ10 Total 27923-2
36765 Interpretation (TQ10) 59462-2
36777 Reviewed By 18771-6

Secondary ID

63148